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Morphology study of progesterone polymorphs prepared by polymer-induced heteronucleation (PIHn)

Authors

  • Andrea M. A. Araya-Sibaja,

    1. Programa de Pós-Graduação em Farmácia, Universidade Federal de Santa Catarina, Florianópolis, Brasil
    2. Escuela de Química, Universidad de Costa Rica, San José, Costa Rica
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  • Cinira Fandaruff,

    1. Programa de Pós-Graduação em Farmácia, Universidade Federal de Santa Catarina, Florianópolis, Brasil
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  • Carlos E. M. Campos,

    1. Programa de Pós-Graduação em Física, Universidade Federal de Santa Catarina, Florianópolis, Brasil
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  • Valdir Soldi,

    1. Grupo de estudo em materiais poliméricos (POLIMAT), Departamento de Química, Universidade Federal de Santa Catarina, Florianópolis, Brasil
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  • Simone G. Cardoso,

    1. Programa de Pós-Graduação em Farmácia, Universidade Federal de Santa Catarina, Florianópolis, Brasil
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  • Silvia L. Cuffini

    Corresponding author
    1. CONICET, Ministerio de Ciencia y Técnica de Córdoba, Córdoba, Argentina
    • Programa de Pós-Graduação em Farmácia, Universidade Federal de Santa Catarina, Florianópolis, Brasil
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  • Contract grant sponsor: CNPq; Contract grant sponsor: CAPES; Contract grant sponsor: FAPESC; Contract grant sponsor: CLAF Contract grant sponsor: Fundación Sauberan; Contract grant sponsor: CONICET.

Address for reprints: Silvia Lucia Cuffini, Programa de Pos-Graduação em Farmácia, Universidade Federal de Santa Catarina, Campus Reitor João David Ferreira Lima, Rua Delfino Conti, s/n. CEP 88040–970, Florianópolis, Brasil E-mail: scuffini@gmail.com

Summary

In this article, morphology of progesterone polymorphs prepared by polymer-induced heteronucleation (PIHn) technique was studied. Hydroxypropyl methylcellulose(HPMC), such as dextran T-500 and gelatin G-9382, polyisoprene (PI), and acrylonitrile/butadiene copolymer (NBR) were used as substrates. The crystallizations were performed by solvent evaporation at room temperature from 0.5, 10, and 40 mg/ml solutions in chloroform and acetone. Progesterone polymorphs were identified by X-ray diffraction. Differential scanning calorimetry and total attenuated reflectance infrared spectroscopy were used as complementary techniques in the identification. Depending on the polymeric matrix and the concentration used, form 1, form 2, or mixture of both polymorphs were obtained. Scanning electron microscopy pictures evidenced difference in morphology and in homogeneity of the two progesterone polymorphs. These polymorphs prepared by PIHn, did not present a distinctive morphology that allows identifying polymorph by its crystal habit. Hence, polymeric matrix induced the crystallization, affecting polymorphism and morphology. SCANNING 35:213-221, 2013. © 2012 Wiley Periodicals, Inc.

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