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Second harmonic microscopic imaging and spectroscopic characterization in prostate pathological tissue

Authors

  • Yanyue Huang,

    1. Laboratory of Photonic Information Technology, South China Normal University, Guangzhou, Guangdong, China
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  • Zhengfei Zhuang

    Corresponding author
    1. Laboratory of Photonic Chinese Medicine, College of Biophotonics, South China Normal University, Guangzhou, China
    • Address for reprints: Zhengfei Zhuang, Laboratory of Photonic Chinese Medicine, College of Biophotonics, South China Normal University, Guangzhou 510631, China

      E-mail: zhuangzhf@yahoo.com.cn

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Summary

Second harmonic microscopic imaging and spectroscopy technology has become a powerful tool for biomedical studies, especially in cancer research. In this paper, second harmonic generation in benign prostatic hyperplasia (BPH) and prostate cancer (PC) tissues in mouse model (C57BL6) have been reported. Excitated samples with different wavelength near-infrared laser from 780 to 850 nm we found that second harmonic signals from BPH nuclei stronger than that from PC, and a wavelength sensitivity was also observed in this experiment. Providing useful help for prostate malignancy diagnosis and identifying tissue components on clinic. SCANNING 36:334–337, 2014. © 2013 Wiley Periodicals, Inc.

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