SIMS proceedings paper
Lipid compounds analysis with MeV-SIMS apparatus for biological applications
Article first published online: 10 APR 2014
Copyright © 2014 John Wiley & Sons, Ltd.
Surface and Interface Analysis
Special Issue: Proceedings of the Nineteenth International Conference on Secondary Ion Mass Spectrometry, SIMS XIX, Jeju, Korea, September 29–October 4, 2013
Volume 46, Issue S1, pages 353–356, November 2014
How to Cite
2014) Lipid compounds analysis with MeV-SIMS apparatus for biological applications, Surf. Interface Anal., 46, pages 353–356, doi: 10.1002/sia.5524., , , , , , and (
- Issue published online: 25 NOV 2014
- Article first published online: 10 APR 2014
- Manuscript Accepted: 15 MAR 2014
- Manuscript Revised: 5 MAR 2014
- Manuscript Received: 13 NOV 2013
- detection limit;
Secondary ion mass spectrometry (SIMS) is one of the powerful methods that can be applied to high sensitivity mass analysis and high-spatial resolution mass imaging. For the analysis of minor components of the complex biological samples, however, superior sensitivity with low background is required. We have developed an MeV-SIMS apparatus with distinctively high secondary ion yield for large organic molecules. In this study, the detection limit of our original MeV-SIMS apparatus was investigated using compounds of two lipids. In the acquired mass spectra, the molecular ions of both lipids were clearly observed with high quantitativity. In addition, the results were compared with conventional time-of-flight-SIMS results. As a result, the detection limit of MeV-SIMS apparatus was found to be below 0.1% and was much lower than that of the conventional Bi cluster SIMS. Copyright © 2014 John Wiley & Sons, Ltd.