Network meta-analysis for indirect treatment comparisons
Article first published online: 26 JUL 2002
Copyright © 2002 John Wiley & Sons, Ltd.
Statistics in Medicine
Volume 21, Issue 16, pages 2313–2324, 30 August 2002
How to Cite
Lumley, T. (2002), Network meta-analysis for indirect treatment comparisons. Statist. Med., 21: 2313–2324. doi: 10.1002/sim.1201
- Issue published online: 26 JUL 2002
- Article first published online: 26 JUL 2002
- Manuscript Accepted: NOV 2001
- Manuscript Received: APR 2001
- mixed model;
- random effects model;
- controlled trial
I present methods for assessing the relative effectiveness of two treatments when they have not been compared directly in a randomized trial but have each been compared to other treatments. These network meta-analysis techniques allow estimation of both heterogeneity in the effect of any given treatment and inconsistency (‘incoherence’) in the evidence from different pairs of treatments. A simple estimation procedure using linear mixed models is given and used in a meta-analysis of treatments for acute myocardial infarction. Copyright © 2002 John Wiley & Sons, Ltd.