Issues in the meta-analysis of cluster randomized trials
Article first published online: 20 SEP 2002
Copyright © 2002 John Wiley & Sons, Ltd.
Statistics in Medicine
Special Issue: 9th International Symposium on Long-Term Clinical Trials
Volume 21, Issue 19, pages 2971–2980, 15 October 2002
How to Cite
Donner, A. and Klar, N. (2002), Issues in the meta-analysis of cluster randomized trials. Statist. Med., 21: 2971–2980. doi: 10.1002/sim.1301
- Issue published online: 20 SEP 2002
- Article first published online: 20 SEP 2002
- Natural Sciences and Engineering Research Council of Canada
- community trials;
- intraclass correlation;
- correlated binary data
Meta-analyses involving the synthesis of evidence from cluster randomization trials are being increasingly reported. These analyses raise challenging methodologic issues beyond those raised by meta-analyses which include only individually randomized trials. In this paper we review and comment on a selected number of these issues, including problems of study heterogeneity, difficulties in estimating design effects from individual trials and the choice of statistical methods. Copyright © 2002 John Wiley & Sons, Ltd.