Medical diagnostic testing models for multifactorial disease classifications
Article first published online: 18 JUL 2005
Copyright © 2005 John Wiley & Sons, Ltd.
Statistics in Medicine
Volume 24, Issue 17, pages 2649–2657, 15 September 2005
How to Cite
Hutson, A. D. (2005), Medical diagnostic testing models for multifactorial disease classifications. Statist. Med., 24: 2649–2657. doi: 10.1002/sim.2133
- Issue published online: 24 AUG 2005
- Article first published online: 18 JUL 2005
- Manuscript Accepted: OCT 2004
- Manuscript Received: AUG 2004
- NYSTAR Faculty Development Grant
- disease classification;
- diagnostic markers;
- ROC analysis
In this note we extend the logistic regression receiver operating characteristic (ROC) analysis framework to diagnosing disease that can be classified in a 2 × 2 factorial setting. Similar to the standard ROC curve analysis these new models accommodate prediction of cross-classifications for treatment success and diagnosis of disease. A didactic example is given for jointly diagnosing malaria positive and respiratory distress in children in Ghana. Copyright © 2005 John Wiley & Sons, Ltd.