Statistics in Medicine is 25 years old. We now begin the 26th year with more enthusiasm than any other period in the journal's history. We have attained and maintain our stature as a leading journal in biostatistics. Our objective of publishing articles motivated by real-world examples and including methods immediately applicable to medical problems continues to make us useful, unique and in high demand. Articles written by leading statisticians and new scholars appear in each issue.

The review process continues to improve. Our shift to online submission has been successful. The new associate editors have acclimated extremely well. More rapid decisions are being made and putting accepted papers online makes dissemination almost immediate. We will continue to add to the impressive list of associate editors and to make the online submission and review process smoother and more reliable.

Submissions continue to increase and the quality of the manuscripts is higher than ever. We have developed a backlog of accepted papers. To address this the journal has increased its frequency from 24 to 30 issues. The goal is to make Statistics in Medicine the leader in review and publication time. The structure and resources for a rapid and smooth review and publication process have been identified and allocated.

The content of the journal has been continuously evolving. The mainstay of the journal is unsolicited articles. We cover all the fields of biostatistics including clinical trials, observational studies, epidemiology, genetics, health services, survival analysis, longitudinal methods, random effects models, predictive analysis, frequentist and Bayesian methods and emerging fields such as bioinformatics. The tutorials, an extremely popular feature of the journal, will continue at an increasing rate. Further, invited review articles on current topics will increase, as will opinion pieces on contemporary and/or controversial topics. For our 25th anniversary we invited and published papers on Bayesian methods, genetics methods, clinical trials, regulatory issues and numerous other topics. These invited papers proved to be extremely popular and they will continue. The present issue contains two such current topics articles, one by editor Michael Campbell, with Alan Donner and Neils Klar, on cluster randomized trials and a second by Donald Rubin on the use of observational studies to extract causal effects. We are sure these will be as impressive as the articles published last year.

In closing, we thank the founding editors, Tony Johnson, Laurence Freedman and Ted Colton, for their impressive vision and achievements. We take pride in continuing their journal through the first 25 years and look forward to the next 25.