This article was published online on 16 June 2010. An error was subsequently identified. This notice is included in the online and print versions to indicate that both have been corrected on 28 July 2010.
Comparative effectiveness research: Policy context, methods development and research infrastructure†
Article first published online: 16 JUN 2010
Copyright © 2010 John Wiley & Sons, Ltd.
Statistics in Medicine
Volume 29, Issue 19, pages 1963–1976, 30 August 2010
How to Cite
Tunis, S. R., Benner, J. and McClellan, M. (2010), Comparative effectiveness research: Policy context, methods development and research infrastructure. Statist. Med., 29: 1963–1976. doi: 10.1002/sim.3818
- Issue published online: 29 JUL 2010
- Article first published online: 16 JUN 2010
- Manuscript Accepted: 6 NOV 2009
- Manuscript Received: 14 OCT 2009
- clinical research;
- research methods;
- research infrastructure
Comparative effectiveness research (CER) has received substantial attention as a potential approach for improving health outcomes while lowering costs of care, and for improving the relevance and quality of clinical and health services research. The Institute of Medicine defines CER as ‘the conduct and synthesis of systematic research comparing different interventions and strategies to prevent, diagnose, treat, and monitor health conditions. The purpose of this research is to inform patients, providers, and decision-makers, responding to their expressed needs, about which interventions are most effective for which patients under specific circumstances.’ Improving the methods and infrastructure for CER will require sustained attention to the following issues: (1) Meaningful involvement of patients, consumers, clinicians, payers, and policymakers in key phases of CER study design and implementation; (2) Development of methodological ‘best practices’ for the design of CER studies that reflect decision-maker needs and balance internal validity with relevance, feasibility and timeliness; and (3) Improvements in research infrastructure to enhance the validity and efficiency with which CER studies are implemented. The approach to addressing each of these issues should be informed by the understanding that the primary purpose of CER is to help health care decision makers make informed clinical and health policy decisions. Copyright © 2010 John Wiley & Sons, Ltd.