This article is a U.S. government work and is in the public domain in the USA.
Special Issue Paper
Ecological-type inference in matched-pair studies with fixed marginal totals†
Article first published online: 10 FEB 2011
This article is a U.S. government work and is in the public domain in the USA. Published in 2011 by John Wiley & Sons, Ltd.
Statistics in Medicine
Special Issue: 13th Biennial CDC & ATSDR Symposium on Statistical Methods Info-Fusion: Utilization of Multi-Source Data
Volume 30, Issue 5, pages 541–548, 28 February 2011
How to Cite
Barker, L. K., Griffin, S. O., Jeon, S., Gray, S. K. and Vidakovic, B. (2011), Ecological-type inference in matched-pair studies with fixed marginal totals. Statist. Med., 30: 541–548. doi: 10.1002/sim.3919
- Issue published online: 10 FEB 2011
- Article first published online: 10 FEB 2011
- Manuscript Accepted: 23 FEB 2010
- Manuscript Received: 19 FEB 2010
- matched-pair study;
- Bayesian inference;
- hierarchical model;
- ecological inference;
- Markov chain Monte Carlo;
- dental sealants meta-analysis
This paper applies a Bayesian approach to ecological-type inference in matched-pair studies because traditional methods that assume parallel tables are not directly applicable. The proposed procedure is based on a hierarchical Bayes structure which models information about the within-pair association. The proposed algorithm relies on Markov chain Monte Carlo simulation, recovers the full table, and reports its accuracy in terms of credible sets for the cell counts. This methodology is motivated and illustrated with examples from split-mouth designs assessing the effectiveness of dental sealant materials and cross-over trials comparing two forms of insulin. Published in 2011 by John Wiley & Sons, Ltd.