A statistical assessment of clinical equivalence
Article first published online: 12 OCT 2006
Copyright © 1988 John Wiley & Sons, Ltd.
Statistics in Medicine
Volume 7, Issue 12, pages 1267–1277, December 1988
How to Cite
Mau, J. (1988), A statistical assessment of clinical equivalence. Statist. Med., 7: 1267–1277. doi: 10.1002/sim.4780071207
- Issue published online: 12 OCT 2006
- Article first published online: 12 OCT 2006
- Manuscript Revised: MAR 1988
- Manuscript Received: MAR 1987
- Deutsche Forschungsgemeinschaft
- Clinical equivalence;
- Confidence intervals;
- Strength of evidence
An observed confidence distribution is proposed as a measure of strength of evidence for practically equivalent efficacies of two treatments. The concept is independent of prior opinions about relevant sizes of a difference in efficacy. It also avoids retrospective power calculations for trials with missed recruitment goals and allows combination of the confidence from independent experiments.