Surrogate endpoints in clinical trials: Ophthalmologic disorders
Article first published online: 12 OCT 2006
Copyright © 1989 John Wiley & Sons, Ltd.
Statistics in Medicine
Volume 8, Issue 4, pages 427–430, April 1989
How to Cite
Hillis, A. and Seigel, D. (1989), Surrogate endpoints in clinical trials: Ophthalmologic disorders. Statist. Med., 8: 427–430. doi: 10.1002/sim.4780080406
- Issue published online: 12 OCT 2006
- Article first published online: 12 OCT 2006
- Manuscript Revised: AUG 1988
- Manuscript Received: DEC 1987
- Surrogate variables;
- Clinical trials;
- Early changes;
- Intraocular pressure
We examined three examples of surrogate observations in ophthalmology. The first'represents a simple case: the status of one eye is used as a surrogate for the (unobservable) status of the opposite eye in the same individual. The second and third examples represent possible extrapolation of long term results on the basis of early changes. These examples are used to illustrate the assumptions intrinsic in the use of surrogate variables.