Latent class analysis of diagnostic agreement
Article first published online: 12 OCT 2006
Copyright © 1990 John Wiley & Sons, Ltd.
Statistics in Medicine
Volume 9, Issue 5, pages 559–572, May 1990
How to Cite
Uebersax, J. S. and Grove, W. M. (1990), Latent class analysis of diagnostic agreement. Statist. Med., 9: 559–572. doi: 10.1002/sim.4780090509
- Issue published online: 12 OCT 2006
- Article first published online: 12 OCT 2006
- Manuscript Revised: NOV 1989
- Manuscript Received: NOV 1988
- RAND Corporation
We describe methods based on latent class analysis for analysis and interpretation of agreement on dichotomous diagnostic ratings. This approach formulates agreement in terms of parameters directly related to diagnostic accuracy and leads to many practical applications, such as estimation of the accuracy of individual ratings and the extent to which accuracy may improve with multiple opinions. We describe refinements in the estimation of parameters for varying panel designs, and apply latent class methods successfully to examples of medical agreement data that include data previously found to be poorly fitted by two-class models. Latent class techniques provide a powerful and flexible set of tools to analyse diagnostic agreement and one should consider them routinely in the analysis of such data.