A general parametric approach to the meta-analysis of randomized clinical trials
Article first published online: 12 OCT 2006
Copyright © 1991 John Wiley & Sons, Ltd.
Statistics in Medicine
Volume 10, Issue 11, pages 1665–1677, November 1991
How to Cite
Whitehead, A. and Whitehead, J. (1991), A general parametric approach to the meta-analysis of randomized clinical trials. Statist. Med., 10: 1665–1677. doi: 10.1002/sim.4780101105
- Issue published online: 12 OCT 2006
- Article first published online: 12 OCT 2006
Meta-analysis provides a systematic and quantitative approach to the summary of results from randomized studies. Whilst many authors have published actual meta-analyses concerning specific therapeutic questions, less has been published about comprehensive methodology. This article presents a general parametric approach, which utilizes efficient score statistics and Fisher's information, and relates this to different methods suggested by previous authors. Normally distributed, binary, ordinal and survival data are considered. Both the fixed effects and random effects model for treatments are described.