Construction of age-related reference centiles using absolute residuals
Article first published online: 12 OCT 2006
Copyright © 1993 John Wiley & Sons, Ltd.
Statistics in Medicine
Volume 12, Issue 10, pages 917–924, 30 May 1993
How to Cite
Altman, D. G. (1993), Construction of age-related reference centiles using absolute residuals. Statist. Med., 12: 917–924. doi: 10.1002/sim.4780121003
- Issue published online: 12 OCT 2006
- Article first published online: 12 OCT 2006
- Manuscript Revised: SEP 1992
- Manuscript Received: OCT 1991
This paper proposes a simple approach to the parametric derivation of age-related reference ranges which avoids the creation of arbitrary age groups, copes easily with a non-linear relation between variability and age, and is computationally simple. After the mean is modelled as a function of age, the age-specific standard deviation is estimated by regressing the absolute residuals on age. The method assumes that the data are, or can be transformed to be, normal at each age, and uses the properties of the half normal distribution. An example is given using 450 measurements of fetal foot length.