Statistical issues in assessing comorbidity
Article first published online: 28 FEB 2007
Copyright © 1995 John Wiley & Sons, Ltd.
Statistics in Medicine
Volume 14, Issue 8, pages 721–733, 30 April 1995
How to Cite
Kraemer, H. C. (1995), Statistical issues in assessing comorbidity. Statist. Med., 14: 721–733. doi: 10.1002/sim.4780140803
- Issue published online: 28 FEB 2007
- Article first published online: 28 FEB 2007
- Manuscript Revised: MAY 1994
- Manuscript Received: NOV 1992
- Clinical Research Center for the Study of Senile Dementia. Grant Number: MH40041
I define three separate and distinct types of non-random comorbidity: epidemiologic, clinical and familial. These might exist singly or in any combination for a pair of disorders. The focus is on their definition and the measurement and interpretation of the types of comorbidity of most common concern: epidemiologic comorbidity. I discuss certain sources of epidemiologic comorbidity such as shared risk factors, or diagnostic ‘fuzziness’, and I indicate the directions of research design and analyses to disclose such sources.