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Commentary: How the debate about comparative effectiveness research should impact the future of clinical trials


Michael S. Lauer, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Room 8128, Bethesda, MD 20892, U.S.A.



Comparative effectiveness research represents the kind of research that arguably more directly affects clinical practice and policy. It includes observational studies, clinical trials, and systematic syntheses of existing literature. In this commentary, I argue for the ongoing and critical role of randomization in comparative effectiveness, noting the key differences between practical and explanatory trials. Copyright © 2012 John Wiley & Sons, Ltd.