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Keywords:

  • agreement;
  • confidence interval;
  • interrater;
  • intrarater;
  • measurements;
  • reliability;
  • reproducibility

The number of subjects required to estimate the intraclass correlation coefficient in a reliability study has usually been determined on the basis of the expected width of a confidence interval. However, this approach fails to explicitly consider the probability of achieving the desired interval width and may thus provide sample sizes that are too small to have adequate chance of achieving the desired precision. In this paper, we present a method that explicitly incorporates a prespecified probability of achieving the prespecified width or lower limit of a confidence interval. The resultant closed-form formulas are shown to be very accurate. Copyright © 2012 John Wiley & Sons, Ltd.