Special Issue Paper
Article first published online: 16 JUL 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Statistics in Medicine
Special Issue: Papers from the 2010 National Heart, Lung and Blood Institute Clinical Trial Workshop
Volume 31, Issue 25, pages 3062–3065, 10 November 2012
How to Cite
Kunz, L. M., Yeh, R. W. and Normand, S.-L. T. (2012), Comparative effectiveness research: does one size fit all?. Statist. Med., 31: 3062–3065. doi: 10.1002/sim.5482
- Issue published online: 11 OCT 2012
- Article first published online: 16 JUL 2012
- Manuscript Accepted: 15 MAR 2012
- Manuscript Received: 14 MAR 2012
In this commentary, we argue that although randomization has many benefits, not all questions we seek to answer fit into a randomized setting. Our argument utilizes the clinical setting of carotid atherosclerosis management where specific clinical questions are answered by using a variety of comparative effectiveness designs. Observational studies should not be ruled out when designing studies to address questions of comparative effectiveness. Copyright © 2012 John Wiley & Sons, Ltd.