Comparative effectiveness research: does one size fit all?

Authors


Sharon-Lise T. Normand, Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston, MA 02115, U.S.A.

E-mail: sharon@hcp.med.harvard.edu

Abstract

In this commentary, we argue that although randomization has many benefits, not all questions we seek to answer fit into a randomized setting. Our argument utilizes the clinical setting of carotid atherosclerosis management where specific clinical questions are answered by using a variety of comparative effectiveness designs. Observational studies should not be ruled out when designing studies to address questions of comparative effectiveness. Copyright © 2012 John Wiley & Sons, Ltd.

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