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Keywords:

  • Jonckheere statistic;
  • repeated measures;
  • randomized blocks;
  • short time series;
  • patient-reported outcome;
  • profile analysis

Focusing on statistical methods in patient-reported outcomes, we propose and develop a generalized Jonckheere test against ordered alternatives for repeated measures in a randomized block design. We derive its asymptotic null distribution properties and describe methods for estimating the null distribution for testing the hypothesis. We present a numerical example to illustrate the test procedure. Copyright © 2012 John Wiley & Sons, Ltd.