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Research Article

Severity of bias of a simple estimator of the causal odds ratio in Mendelian randomization studies

  1. Roger M. Harbord1,2,
  2. Vanessa Didelez4,
  3. Tom M. Palmer1,2,
  4. Sha Meng3,
  5. Jonathan A.C. Sterne1,
  6. Nuala A. Sheehan3,*

Article first published online: 18 OCT 2012

DOI: 10.1002/sim.5659

Issue

Statistics in Medicine

Statistics in Medicine

Volume 32, Issue 7, pages 1246–1258, 30 March 2013

Additional Information

How to Cite

Harbord, R. M., Didelez, V., Palmer, T. M., Meng, S., Sterne, J. A.C. and Sheehan, N. A. (2013), Severity of bias of a simple estimator of the causal odds ratio in Mendelian randomization studies. Statist. Med., 32: 1246–1258. doi: 10.1002/sim.5659

Author Information

  1. 1

    School of Social and Community Medicine, University of Bristol, Bristol, U.K.

  2. 2

    Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, U.K.

  3. 3

    Department of Health Sciences and Department of Genetics, University of Leicester, Leicester, U.K.

  4. 4

    School of Mathematics, University of Bristol, Bristol, U.K.

* Correspondence to: Nuala A. Sheehan, Department of Health Sciences and Department of Genetics, University of Leicester, Leicester, U.K.
E-mail: nas11@le.ac.uk

Publication History

  1. Issue published online: 11 MAR 2013
  2. Article first published online: 18 OCT 2012
  3. Manuscript Accepted: 26 SEP 2012
  4. Manuscript Received: 12 OCT 2011

Funded by

  • Medical Research Council. Grant Numbers: G0601625, G0600705
  • Research Fellowships. Grant Numbers: RF/9/RFG/2009/0062, RF-2011-320

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View Full Article (HTML) Get PDF (273K)