Article first published online: 7 NOV 2012
Copyright © 2012 John Wiley & Sons, Ltd.
Statistics in Medicine
Volume 32, Issue 12, pages 1995–2000, 30 May 2013
How to Cite
Qu, Y. (2013), Evaluation of a surrogate marker: validity and efficiency. Statist. Med., 32: 1995–2000. doi: 10.1002/sim.5672
- Issue published online: 7 MAY 2013
- Article first published online: 7 NOV 2012
- Manuscript Accepted: 9 OCT 2012
- Manuscript Received: 21 APR 2012
- surrogate endpoint;
- proportion of treatment effect;
- proportion of information gain;
- general association;
- likelihood reduction factor
Statistical validation of a surrogate endpoint or surrogate marker has been studied for three decades. However, there is still no consensus on how to evaluate surrogate endpoints or surrogate markers. There is much confusion on which method should be used for the evaluation of a surrogate endpoint or surrogate marker. In this article, we clarify the statistical definitions of the surrogate endpoint and surrogate marker and introduce the concept of the validity and efficiency of a surrogate marker. We suggest the proportion of information gain can be used to evaluate the validity of a surrogate marker. Copyright © 2012 John Wiley & Sons, Ltd.