A covariate-adjusted response-adaptive allocation in clinical trials for a general class of responses
Article first published online: 19 JUL 2013
Copyright © 2013 John Wiley & Sons, Ltd.
Statistics in Medicine
Volume 32, Issue 29, pages 5053–5061, 20 December 2013
How to Cite
Bandyopadhyay, U. and Bhattacharya, R. (2013), A covariate-adjusted response-adaptive allocation in clinical trials for a general class of responses. Statist. Med., 32: 5053–5061. doi: 10.1002/sim.5900
- Issue published online: 8 NOV 2013
- Article first published online: 19 JUL 2013
- Manuscript Accepted: 13 JUN 2013
- Manuscript Received: 22 MAY 2012
- response-adaptive design;
- covariate-adjusted allocation;
A class of covariate-adjusted adaptive allocation procedures is developed for a general class of responses with an aim to satisfy relevant clinical requirements. Some exact and asymptotic properties of the procedures, proposed and a reasonable competitor, are studied and compared under the presence of treatment-covariate interaction. Copyright © 2013 John Wiley & Sons, Ltd.