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A covariate-adjusted response-adaptive allocation in clinical trials for a general class of responses

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Abstract

A class of covariate-adjusted adaptive allocation procedures is developed for a general class of responses with an aim to satisfy relevant clinical requirements. Some exact and asymptotic properties of the procedures, proposed and a reasonable competitor, are studied and compared under the presence of treatment-covariate interaction. Copyright © 2013 John Wiley & Sons, Ltd.

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