Statistics in Medicine

© John Wiley & Sons, Ltd.

Cover image for Statistics in Medicine

March 1993

Volume 12, Issue 5-6

Pages fmi–fmi, 415–616

  1. Masthead

    1. Top of page
    2. Masthead
    3. Preface
    4. Opening Remarks
    5. Articles
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    1. Masthead (page fmi)

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120501

  2. Preface

    1. Top of page
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    3. Preface
    4. Opening Remarks
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    1. Preface (page 415)

      Susan S. Ellenberg, Nancy Geller, Richard Simon and Salim Yusuf

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120502

  3. Opening Remarks

    1. Top of page
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    25. Closing Remarks
    1. Opening Remarks (page 417)

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120503

  4. Articles

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    25. Closing Remarks
    1. Behind closed doors: The data monitoring board in randomized clinical trials (pages 419–424)

      Janet Wittes

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120504

    2. The NHLBI model: A 25 year history (pages 425–431)

      Lawrence Friedman

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120505

  5. Discussions

    1. Top of page
    2. Masthead
    3. Preface
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    25. Closing Remarks
    1. Discussion (pages 433–434)

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120506

  6. Articles

    1. Top of page
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    25. Closing Remarks
    1. A survey of monitoring practices in cancer clinical trials (pages 435–450)

      Stephen L. George

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120507

    2. Data monitoring committees for southwest oncology group clinical trials (pages 451–455)

      Stephanie Green and John Crowley

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120508

  7. Discussions

    1. Top of page
    2. Masthead
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    25. Closing Remarks
    1. Discussion (pages 457–459)

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120509

  8. Articles

    1. Top of page
    2. Masthead
    3. Preface
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    25. Closing Remarks
    1. The use of external monitoring committees in clinical trials of the national institute of allergy and infectious diseases (pages 461–467)

      Susan S. Ellenberg, Maureen W. Myers, William C. Blackwelder and Daniel F. Hoth

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120510

  9. Discussions

    1. Top of page
    2. Masthead
    3. Preface
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    25. Closing Remarks
    1. Discussion (page 469)

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120511

  10. Articles

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    1. Data monitoring and interim analyses in the pharmaceutical industry: Ethical and logistical considerations (pages 471–479)

      Frank W. Rockhold and Gregory G. Enas

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120512

    2. Monitoring of clinical trials and interim analyses from a drug Sponsor's point of view (pages 481–492)

      George W. Williams, Robert L. Davis, Albert J. Getson, A. Lawrence Gould, Irving K. Hwang, Holly Matthews, Weichung Joseph Shih, Steven M. Snapinn and Karen L. Walton-Bowen

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120513

  11. Discussions

    1. Top of page
    2. Masthead
    3. Preface
    4. Opening Remarks
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    25. Closing Remarks
    1. Discussion (pages 493–495)

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120514

  12. Articles

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    1. Monitoring clinical trials: Experience of, and proposals under consideration by, the cancer therapy committee of the British medical research council (pages 497–504)

      Mahesh K. B. Parmar and David Machin

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120515

    2. The use of data monitoring committees in canadian trial groups (pages 505–508)

      Joseph L. Pater

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120516

    3. Interim analyses, stopping rules and data monitoring in clinical trials in europe (pages 509–520)

      Marc Buyse

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120517

  13. Discussions

    1. Top of page
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    25. Closing Remarks
    1. Discussion (pages 521–525)

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120518

  14. Articles

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    25. Closing Remarks
    1. Panel discussion: The operation of data monitoring committees (pages 527–542)

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120519

    2. Practical issues in data monitoring of clinical trials: Summary of responses to a questionnaire at nih (pages 543–551)

      Nancy L. Geller and Mario Stylianou

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120520

  15. Discussions

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    25. Closing Remarks
    1. Discussion (page 553)

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120521

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    25. Closing Remarks
    1. Data monitoring boards in the pharmaceutical industry (pages 555–561)

      Jay Herson

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120522

  17. Discussions

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    25. Closing Remarks
    1. Discussion (page 563)

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120523

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    25. Closing Remarks
    1. Data monitoring committees and capturing relevant information of high quality (pages 565–570)

      Thomas R. Fleming

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120524

  19. Discussions

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    25. Closing Remarks
    1. Discussion (pages 571–573)

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120525

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    25. Closing Remarks
    1. Data monitoring committees: The moral case for maximum feasible independence (pages 575–580)

      Leroy Walters

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120526

  21. Discussions

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    1. Discussion (pages 581–582)

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120527

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    1. Panel discussion: Scientific issues in data monitoring (pages 583–600)

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120528

    2. Some FDA perspectives on data monitoring in clinical trials in drug development (pages 601–608)

      Robert T. O'neill

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120529

  23. Discussions

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    1. Discussion (pages 609–614)

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120530

  24. Closing Remarks

    1. Top of page
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    1. Closing remarks (pages 615–616)

      Article first published online: 12 OCT 2006 | DOI: 10.1002/sim.4780120531

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