Statistics in Medicine

Cover image for Statistics in Medicine

Special Issue: Statistical Methods in Biopharmacy: Integrating Issues of Efficacy, Safety and Cost-Effectiveness

30 March 2003

Volume 22, Issue 6

Pages 829–1039

Issue edited by: Jean Auclair, Peter Bauer

  1. Research Articles

    1. Top of page
    2. Research Articles
    1. Preface (page 829)

      Jean Auclair and Peter Bauer

      Article first published online: 21 FEB 2003 | DOI: 10.1002/sim.1445

    2. Identifying effective and/or safe doses by stepwise confidence intervals for ratios (pages 847–858)

      Frank Bretz, Ludwig A. Hothorn and Jason C. Hsu

      Article first published online: 21 FEB 2003 | DOI: 10.1002/sim.1449

    3. Two-treatment comparison based on joint toxicity and efficacy ordered alternatives in cancer trials (pages 859–868)

      Alexia Letierce, Pascale Tubert-Bitter, Andrew Kramar and Jean Maccario

      Article first published online: 21 FEB 2003 | DOI: 10.1002/sim.1446

    4. Assessing non-inferiority of a new treatment in a three-arm clinical trial including a placebo (pages 883–899)

      Iris Pigeot, Juliane Schäfer, Joachim Röhmel and Dieter Hauschke

      Article first published online: 21 FEB 2003 | DOI: 10.1002/sim.1450

    5. Assessing individual bioequivalence using the structural equation model (pages 901–912)

      Josep-Lluís Carrasco and Lluís Jover

      Article first published online: 21 FEB 2003 | DOI: 10.1002/sim.1452

    6. Kullback–Leibler divergence for evaluating bioequivalence (pages 913–930)

      Vladimir Dragalin, Valerii Fedorov, Scott Patterson and Byron Jones

      Article first published online: 21 FEB 2003 | DOI: 10.1002/sim.1451

    7. Issues in designing flexible trials (pages 953–969)

      Martin Posch, Peter Bauer and Werner Brannath

      Article first published online: 21 FEB 2003 | DOI: 10.1002/sim.1455

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