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Statistics in Medicine

© John Wiley & Sons, Ltd.

Cover image for Statistics in Medicine

Special Issue: Papers from the 31st Annual Conference of the International Society for Clinical Biostatistics

20-30 May 2012

Volume 31, Issue 11-12

Pages 1001–1305

Issue edited by: Emmanuel Lesaffre, Thomas Gerds

  1. Preface

    1. Top of page
    2. Preface
    3. Special Issue Papers
    4. Letters to the Editor
    5. Special Issue Papers
    1. Preface (page 1001)

      Emmanuel Lesaffre and Thomas Gerds

      Article first published online: 15 MAY 2012 | DOI: 10.1002/sim.5367

  2. Special Issue Papers

    1. Top of page
    2. Preface
    3. Special Issue Papers
    4. Letters to the Editor
    5. Special Issue Papers
    1. Bayesian adaptive clinical trials: a dream for statisticians only? (pages 1002–1013)

      Sylvie Chevret

      Article first published online: 9 SEP 2011 | DOI: 10.1002/sim.4363

    2. Comparison of alternative models for linking drug exposure with adverse effects (pages 1014–1030)

      Michal Abrahamowicz, Marie-Eve Beauchamp and Marie-Pierre Sylvestre

      Article first published online: 17 NOV 2011 | DOI: 10.1002/sim.4343

    3. Optimal sample sizes for phase II clinical trials and pilot studies (pages 1031–1042)

      Nigel Stallard

      Article first published online: 3 NOV 2011 | DOI: 10.1002/sim.4357

    4. Design evaluation and optimisation in crossover pharmacokinetic studies analysed by nonlinear mixed effects models (pages 1043–1058)

      Thu Thuy Nguyen, Caroline Bazzoli and France Mentré

      Article first published online: 3 OCT 2011 | DOI: 10.1002/sim.4390

    5. Non-compartmental estimation of pharmacokinetic parameters for flexible sampling designs (pages 1059–1073)

      Thomas Jaki and Martin J. Wolfsegger

      Article first published online: 3 OCT 2011 | DOI: 10.1002/sim.4386

    6. Interpretability and importance of functionals in competing risks and multistate models (pages 1074–1088)

      Per Kragh Andersen and Niels Keiding

      Article first published online: 14 NOV 2011 | DOI: 10.1002/sim.4385

    7. You have full text access to this OnlineOpen article
      Competing risks and the clinical community: irrelevance or ignorance? (pages 1089–1097)

      Michael T. Koller, Heike Raatz, Ewout W. Steyerberg and Marcel Wolbers

      Article first published online: 23 SEP 2011 | DOI: 10.1002/sim.4384

    8. Optimum threshold estimation based on cost function in a multistate diagnostic setting (pages 1098–1109)

      Konstantina Skaltsa, Lluís Jover, David Fuster and Josep Lluís Carrasco

      Article first published online: 21 SEP 2011 | DOI: 10.1002/sim.4369

  3. Letters to the Editor

    1. Top of page
    2. Preface
    3. Special Issue Papers
    4. Letters to the Editor
    5. Special Issue Papers
    1. ‘Optimum threshold estimation based on cost function in a multistate diagnostic setting’ by K. Skaltsa, L. Jover, D. Fuster and J. L. Carrasco (pages 1110–1112)

      B. Shinkins, R. Stevens and R. Perera

      Article first published online: 15 MAY 2012 | DOI: 10.1002/sim.4483

  4. Special Issue Papers

    1. Top of page
    2. Preface
    3. Special Issue Papers
    4. Letters to the Editor
    5. Special Issue Papers
    1. Performance of binary markers for censored failure time outcome: nonparametric approach based on proportions (pages 1113–1128)

      Laura Antolini and Maria Grazia Valsecchi

      Article first published online: 12 DEC 2011 | DOI: 10.1002/sim.4443

    2. Effect of dependent errors in the assessment of diagnostic or screening test accuracy when the reference standard is imperfect (pages 1129–1138)

      S.D. Walter, P. Macaskill, Sarah J. Lord and L. Irwig

      Article first published online: 21 FEB 2012 | DOI: 10.1002/sim.4444

    3. Estimating survival of dental fillings on the basis of interval-censored data and multi-state models (pages 1139–1149)

      Pierre Joly, Thomas A. Gerds, Vibeke Qvist, Daniel Commenges and Niels Keiding

      Article first published online: 23 FEB 2012 | DOI: 10.1002/sim.4459

    4. An evaluation of penalised survival methods for developing prognostic models with rare events (pages 1150–1161)

      G. Ambler, S. Seaman and R. Z. Omar

      Article first published online: 14 OCT 2011 | DOI: 10.1002/sim.4371

    5. General joint frailty model for recurrent event data with a dependent terminal event: Application to follicular lymphoma data (pages 1162–1176)

      Yassin Mazroui, Simone Mathoulin-Pelissier, Pierre Soubeyran and Virginie Rondeau

      Article first published online: 3 FEB 2012 | DOI: 10.1002/sim.4479

    6. Estimating the number of true discoveries in genome-wide association studies (pages 1177–1189)

      Woojoo Lee, A. Gusnanto, A. Salim, P. Magnusson, Xueling Sim, E.S. Tai and Y. Pawitan

      Article first published online: 11 OCT 2011 | DOI: 10.1002/sim.4391

    7. A two-stage mixed-effects model approach for gene-set analyses in candidate gene studies (pages 1190–1202)

      Roula Tsonaka, Annette H. M. van der Helm-van Mil and Jeanine J. Houwing-Duistermaat

      Article first published online: 14 OCT 2011 | DOI: 10.1002/sim.4370

    8. Local sparse bump hunting reveals molecular heterogeneity of colon tumors (pages 1203–1220)

      Jean-Eudes Dazard, J. Sunil Rao and Sanford Markowitz

      Article first published online: 3 NOV 2011 | DOI: 10.1002/sim.4389

    9. Hierarchical Bayesian formulations for selecting variables in regression models (pages 1221–1237)

      Veronika Rockova, Emmanuel Lesaffre, Jolanda Luime and Bob Löwenberg

      Article first published online: 25 JAN 2012 | DOI: 10.1002/sim.4439

    10. You have full text access to this OnlineOpen article
      Identifying influential observations in Bayesian models by using Markov chain Monte Carlo (pages 1238–1248)

      Dan Jackson, Ian R. White and James Carpenter

      Article first published online: 8 SEP 2011 | DOI: 10.1002/sim.4356

    11. Multilevel latent variable models for global health-related quality of life assessment (pages 1249–1264)

      Annette Kifley, Gillian Z. Heller, Ken J. Beath, David Bulger, Jun Ma and Val Gebski

      Article first published online: 3 FEB 2012 | DOI: 10.1002/sim.4455

    12. How to deal with double partial verification when evaluating two index tests in relation to a reference test? (pages 1265–1276)

      Nan van Geloven, Kimiko A. Broeze, Brent C. Opmeer, Ben Willem Mol and Aeilko H. Zwinderman

      Article first published online: 12 DEC 2011 | DOI: 10.1002/sim.4440

    13. Towards power and sample size calculations for the comparison of two groups of patients with item response theory models (pages 1277–1290)

      Jean-Benoit Hardouin, Sarah Amri, Mohand-Larbi Feddag and Véronique Sébille

      Article first published online: 8 NOV 2011 | DOI: 10.1002/sim.4387

    14. The value of reusing prior nested case–control data in new studies with different outcome (pages 1291–1302)

      Agus Salim, Qian Yang and Marie Reilly

      Article first published online: 21 FEB 2012 | DOI: 10.1002/sim.4494

    15. Considerations on what constitutes a ‘qualified statistician’ in regulatory guidelines (pages 1303–1305)

      Christoph Gerlinger, Lutz Edler, Tim Friede, Meinhard Kieser, Christos T Nakas, Martin Schumacher, Jørgen Seldrup and Norbert Victor

      Article first published online: 21 SEP 2011 | DOI: 10.1002/sim.4345

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