Reactive oxygen species (ROS) and aging: Do we need them — can we measure them — should we block them?
Article first published online: 30 JUN 2005
Copyright © 2005 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Special Issue: Signaling processes during aging
Volume 5, Issue 3, pages 115–125, August 2005
How to Cite
Simm, A. and Brömme, H.-J. (2005), Reactive oxygen species (ROS) and aging: Do we need them — can we measure them — should we block them?. Signal Transduction, 5: 115–125. doi: 10.1002/sita.200400053
- Issue published online: 9 AUG 2005
- Article first published online: 30 JUN 2005
- Manuscript Accepted: JUN 2005
- Manuscript Received: MAY 2005
- superoxide anion;
- cellular signalling
Reactive oxygen species (ROS) are derivatives of oxygen which arise during life in an oxygenated environment. Whereas there is a long discussion within the scientific community about the causes of aging, there is an impressive amount of data indicating that ROS are indeed a major cause for aging. An increase in radical production or a decrease in the defense against ROS appears to be associated with the decrease of the life span of an organism. On the other hand, in the last 15 years, it was shown that radicals are needed for cellular function. Therefore this review concentrates on the arguments for the link between ROS and aging, the hazardous nature of individual radicals, the possibility to analyze ROS and a short view on the impact of ROS on cellular functions.