Eleutherococcus senticosus reduces cardiovascular stress response in healthy subjects: a randomized, placebo-controlled trial
Article first published online: 5 FEB 2002
Copyright © 2002 John Wiley & Sons, Ltd.
Stress and Health
Volume 18, Issue 1, pages 11–17, February 2002
How to Cite
Facchinetti, F., Neri, I. and Tarabusi, M. (2002), Eleutherococcus senticosus reduces cardiovascular stress response in healthy subjects: a randomized, placebo-controlled trial. Stress and Health, 18: 11–17. doi: 10.1002/smi.914
- Issue published online: 5 FEB 2002
- Article first published online: 5 FEB 2002
- Manuscript Accepted: 29 AUG 2001
- Manuscript Received: 13 FEB 2001
- Giuliani S.p.A.
- cardiovascular response;
- Eleutherococcus senticosus;
- complementary medicine;
- sex dimorphism
The number of studies devoted to the scientific evaluation of phytotherapy is rapidly increasing since Western patients seem more oriented towards so-called ‘alternative medicine’. Bearing such arguments in mind we decided to address attention to Eleutherococcus senticosus, a root of the Ginseng family known for thousands of years in China as a remedy for psychological distress. Forty-five paid, healthy volunteers (20 males, 25 females) were recruited. Entry criteria were: good health, age 18–30 years, student and a Symptoms Rating Test score <10. At screening evaluation subjects were randomized to receive orally either placebo (Pl group) or Eleutherococcus senticosus (Es group) for 30 days, in a double-blind design. Subjects were submitted to a stressful cognitive task, the Stroop Colour–Word test (Stroop CW), both before and after treatment. Stroop CW increased heart rate (HR) and systolic BP in every subject. In females there was a greater response than in males in terms of both systolic and diastolic BP. For both genders, the HR response to Stroop CW was reduced by Es treatment while no changes were found after Pl. In females, systolic BP was also reduced in Es group while it remained unchanged in Pl group. This study demonstrated that treatment with Eleutherococcus senticosus is able to reduce cardiovascular responses to stress in healthy young volunteers, while placebo was ineffective. Eleutherococcus senticosus is confirmed to be helpful for stress adaptation. Copyright © 2002 John Wiley & Sons, Ltd.