Flow Focusing: A Versatile Technology to Produce Size-Controlled and Specific-Morphology Microparticles


  • This work has been funded by the Spanish Ministerio de Ciencia y Tecnología (Projects DPI2002-04305-C02-02 and DPI2000-0392-P4-03), Flow Focusing Inc., Kraft Foods Inc., and Biomedal SL. L.M.-B. and A.R.-G. are grateful for financial support from the Spanish Ministerio de Ciencia y Tecnología and University of Sevilla-El Monte Foundation grants for researchers formation. The authors acknowledge the role of R. Bocanegra, J. L. Sampedro, and Dr. M. Marquez in the experiments on multiple-core particles.


The Flow Focusing platform is especially advantageous for micro- and nanoparticle production. This versatile technique is amenable to designing the size, surface treatment and internal topology of the particles; mechanical stresses are minimal—an optimal feature for the manipulation of delicate substances. Multiplexing and high-rate production are readily implemented. Adaptive operational design can lead, in one single step, to finely tuned microcapsules encasing different products within a targeted morphology. This achievement is of great significance for most microcapsule applications in the biosciences (for example, drug delivery, cell encapsulation, and the production of bead arrays).