Communication

Cellular Uptake and Toxicity of Au55 Clusters†

  1. Maria Tsoli Dr.2,
  2. Hubert Kuhn Dr.2,
  3. Wolfgang Brandau Prof.3,
  4. Helmut Esche Prof.4,
  5. Günter Schmid Prof.1

Article first published online: 1 JUL 2005

DOI: 10.1002/smll.200500104

Issue

Small

Small

Volume 1, Issue 8-9, pages 841–844, August 2005

Additional Information

How to Cite

Tsoli, M., Kuhn, H., Brandau, W., Esche, H. and Schmid, G. (2005), Cellular Uptake and Toxicity of Au55 Clusters. Small, 1: 841–844. doi: 10.1002/smll.200500104

Author Information

  1. 1

    University of Duisburg-Essen, Institute for Inorganic Chemistry, Universitätsstr. 5–7, 45117 Essen, Germany, Fax: (+49) 201-183-4195

  2. 2

    Universität-GH Essen, Institut für Physikalische Chemie, Abt. Molecular Modeling, Schützenbahn 70 (Raum L-402), 45117 Essen, Germany

  3. 3

    Klinik und Poliklinik für Nuklearmedizin, Universitätsklinikum Essen, Hufelandstr. 55, 45122 Essen, Germany

  4. 4

    Institut für Molekularbiologie, Universitätsklinikum Essen, Hufelandstr. 55, 45122 Essen, Germany

  1. †

    We acknowledge financial support from the Deutsche Forschungsgemeinschaft, Graduiertenkolleg 689/1.

Publication History

  1. Issue published online: 20 JUL 2005
  2. Article first published online: 1 JUL 2005
  3. Manuscript Received: 30 MAR 2005

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Keywords:

  • antitumor agents;
  • cancer cells;
  • cytotoxicity;
  • gold clusters;
  • radioactivity

Graphical Abstract

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Gold clusters (Au55) have been shown to interact with DNA (see image). Armed with this knowledge, experiments have shown that such clusters are shown to have significant toxicity towards many types of human cells, both healthy and cancerous, in contrast to previously studied larger gold nanoparticles. It is hoped, therefore, that there is a future for Au55 clusters in the treatment of certain cancers.

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