These authors contributed equally to this work.
Specific Targeting, Cell Sorting, and Bioimaging with Smart Magnetic Silica Core–Shell Nanomaterials†
Article first published online: 24 NOV 2005
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 2, Issue 2, pages 209–215, February 2006
How to Cite
Yoon, T.-J., Yu, K., Kim, E., Kim, J., Kim, B., Yun, S.-H., Sohn, B.-H., Cho, M.-H., Lee, J.-K. and Park, S. (2006), Specific Targeting, Cell Sorting, and Bioimaging with Smart Magnetic Silica Core–Shell Nanomaterials. Small, 2: 209–215. doi: 10.1002/smll.200500360
This work is supported by the Nano Systems Institute National Core Research Center (NSI-NCRC), Korea Science and Engineering Foundation (KOSEF), Ministry of Science and Technology, Korea (MOST), and MarineBio21, Ministry of Maritime Affairs and Fisheries, Korea (MOMAF). T.-J.Y., K.N.Y., E.H.K., J.S.K., and B.G.K. are grateful for the award of a BK21 fellowship.
- Issue published online: 9 JAN 2006
- Article first published online: 24 NOV 2005
- Manuscript Received: 22 SEP 2005
- cell recognition;
- core–shell materials;
- magnetic properties;
Organic dye-incorporated smart silica-coated core–shell magnetic nanoparticles (MNP@SiO2) having dual-functionality (-PEG/NH2, see Figure) were easily fabricated, and the amine moieties on the NP surface were modified with maleimide functionality for specific covalent immobilization of biopolymers and bioactive small molecules. The sequence-independent immobilization of antibodies (Ab) is highlighted; Ab-modified MNP@SiO2 particles exhibit specific recognition for floating tumor cells or target the membrane of adherent breast cancer cells.