Specific Targeting, Cell Sorting, and Bioimaging with Smart Magnetic Silica Core–Shell Nanomaterials


  • This work is supported by the Nano Systems Institute National Core Research Center (NSI-NCRC), Korea Science and Engineering Foundation (KOSEF), Ministry of Science and Technology, Korea (MOST), and MarineBio21, Ministry of Maritime Affairs and Fisheries, Korea (MOMAF). T.-J.Y., K.N.Y., E.H.K., J.S.K., and B.G.K. are grateful for the award of a BK21 fellowship.


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Organic dye-incorporated smart silica-coated core–shell magnetic nanoparticles (MNP@SiO2) having dual-functionality (-PEG/NH2, see Figure) were easily fabricated, and the amine moieties on the NP surface were modified with maleimide functionality for specific covalent immobilization of biopolymers and bioactive small molecules. The sequence-independent immobilization of antibodies (Ab) is highlighted; Ab-modified MNP@SiO2 particles exhibit specific recognition for floating tumor cells or target the membrane of adherent breast cancer cells.