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Ethylene Glycol-Protected Magnetic Nanoparticles for a Multiplexed Immunoassay in Human Plasma

Authors

  • Po-Chiao Lin,

    1. Institute of Chemistry and Genomic Research Center, Academia Sinica, Sec.2, Academia Rd. Taipei, 115, Taiwan, Fax: (+886) 2-2783-5007
    2. Chemical Biology and Molecular Biophysics, Taiwan International, Graduate Program, Academia Sinica, Taipei, Taiwan
    3. Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan
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  • Po-Hung Chou,

    1. Institute of Chemistry and Genomic Research Center, Academia Sinica, Sec.2, Academia Rd. Taipei, 115, Taiwan, Fax: (+886) 2-2783-5007
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  • Shu-Hua Chen,

    1. Institute of Chemistry and Genomic Research Center, Academia Sinica, Sec.2, Academia Rd. Taipei, 115, Taiwan, Fax: (+886) 2-2783-5007
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  • Hsin-Kai Liao,

    1. Institute of Chemistry and Genomic Research Center, Academia Sinica, Sec.2, Academia Rd. Taipei, 115, Taiwan, Fax: (+886) 2-2783-5007
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  • Kai-Yi Wang,

    1. Institute of Chemistry and Genomic Research Center, Academia Sinica, Sec.2, Academia Rd. Taipei, 115, Taiwan, Fax: (+886) 2-2783-5007
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  • Yu-Ju Chen Dr.,

    1. Institute of Chemistry and Genomic Research Center, Academia Sinica, Sec.2, Academia Rd. Taipei, 115, Taiwan, Fax: (+886) 2-2783-5007
    2. Chemical Biology and Molecular Biophysics, Taiwan International, Graduate Program, Academia Sinica, Taipei, Taiwan
    3. Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan
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  • Chun-Cheng Lin Dr.

    1. Institute of Chemistry and Genomic Research Center, Academia Sinica, Sec.2, Academia Rd. Taipei, 115, Taiwan, Fax: (+886) 2-2783-5007
    2. Chemical Biology and Molecular Biophysics, Taiwan International, Graduate Program, Academia Sinica, Taipei, Taiwan
    3. Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan
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  • This work was supported by the National Science and Technology Program for Nanoscience and Nanotechnology of Academia Sinica and the National Science Council, Taiwan. We also thank C. Y. Chen for assisting in the preparation of the manuscript.

Abstract

original image

An attractive technique: Methoxyethyl-terminated ethylene glycol-protected antibody-conjugated magnetic nanoparticles (as depicted in the image) are demonstrated to act as specific affinity nanoprobes for the multiplexed detection of target proteins in human plasma and are excellent candidates for future clinical nanodiagnostics.

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