Communication

Gold-Conjugated Protein Nanoarrays through Block-Copolymer Lithography: From Fabrication to Biosensor Design†

  1. Jin-Mi Jung1,
  2. Ki Young Kwon1,
  3. Tai-Hwan Ha Dr.2,
  4. Bong Hyun Chung Dr.2,
  5. Hee-Tae Jung Prof.1

Article first published online: 28 JUL 2006

DOI: 10.1002/smll.200600005

Issue

Small

Small

Volume 2, Issue 8-9, pages 1010–1015, August 2006

Additional Information

How to Cite

Jung, J.-M., Kwon, K. Y., Ha, T.-H., Chung, B. H. and Jung, H.-T. (2006), Gold-Conjugated Protein Nanoarrays through Block-Copolymer Lithography: From Fabrication to Biosensor Design. Small, 2: 1010–1015. doi: 10.1002/smll.200600005

Author Information

  1. 1

    Laboratory of Organic Opto-Electronic Materials, Department of Chemical & Biomolecular Engineering (BK-21), Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea, Fax: (+82) 42-869-3910

  2. 2

    Research Center, Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yuseong-gu, Daejeon 305-600, Korea, Fax: (+82) 42-879-8594

  1. †

    This work was supported by grants from the KRIBB Initiative Research Program, CUPS-ERC (KOSEF, Korea), the Protein Chip Technology Program (MOST, Korea), and MOHW (0405-MN01-0604-0007).

Publication History

  1. Issue published online: 28 JUL 2006
  2. Article first published online: 28 JUL 2006
  3. Manuscript Received: 4 JAN 2006

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Keywords:

  • biosensors;
  • block copolymers;
  • lithography;
  • nanoparticles;
  • proteins

Graphical Abstract

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A hole lot of protein: A method to immobilize proteins at defined positions at the single-molecule level has been developed by using templates structured by block-copolymer lithography to generate ultrahigh-density protein nanoarrays (see image). Carbohydrate–lectin (RCA or WGA) interactions on the nanoarray surface have remarkably high selectivity and reproducibility and indicate that this approach is applicable for biosensors.

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