This work was supported by grants from the KRIBB Initiative Research Program, CUPS-ERC (KOSEF, Korea), the Protein Chip Technology Program (MOST, Korea), and MOHW (0405-MN01-0604-0007).
Gold-Conjugated Protein Nanoarrays through Block-Copolymer Lithography: From Fabrication to Biosensor Design†
Article first published online: 28 JUL 2006
Copyright © 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 2, Issue 8-9, pages 1010–1015, August 2006
How to Cite
Jung, J.-M., Kwon, K. Y., Ha, T.-H., Chung, B. H. and Jung, H.-T. (2006), Gold-Conjugated Protein Nanoarrays through Block-Copolymer Lithography: From Fabrication to Biosensor Design. Small, 2: 1010–1015. doi: 10.1002/smll.200600005
- Issue published online: 28 JUL 2006
- Article first published online: 28 JUL 2006
- Manuscript Received: 4 JAN 2006
- block copolymers;
A hole lot of protein: A method to immobilize proteins at defined positions at the single-molecule level has been developed by using templates structured by block-copolymer lithography to generate ultrahigh-density protein nanoarrays (see image). Carbohydrate–lectin (RCA or WGA) interactions on the nanoarray surface have remarkably high selectivity and reproducibility and indicate that this approach is applicable for biosensors.