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Core/Shell Fluorescent Silica Nanoparticles for Chemical Sensing: Towards Single-Particle Laboratories


  • The authors would like to thank the Cornell Center for Materials Research (CCMR), Cornell Biotechnology Resource Center (BRC), and the Cornell Nanobiotechnology Center (NBTC) for facilities usage and the NBTC for funding. This material is based upon work supported by NSF NIRT grant 0404195 and the STC Program of the National Science Foundation under Agreement No. ECS-9876771.


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A fluorescent chemical sensor based upon a core/shell architecture of silica nanoparticles (see figure) is introduced. By covalent attachment of organic reference dyes within the core and sensor dyes in the outer shell, optimal sensor architectures can be realized. This paves the way for the development of highly functional particles with catalytic or synthetic abilities.