Communication

Pt Nanoparticles Functionalized with Nucleic Acid Act as Catalytic Labels for the Chemiluminescent Detection of DNA and Proteins†

  1. Ron Gill,
  2. Ronen Polsky Dr.,
  3. Itamar Willner Prof.

Article first published online: 13 JUL 2006

DOI: 10.1002/smll.200600133

Issue

Small

Small

Volume 2, Issue 8-9, pages 1037–1041, August 2006

Additional Information

How to Cite

Gill, R., Polsky, R. and Willner, I. (2006), Pt Nanoparticles Functionalized with Nucleic Acid Act as Catalytic Labels for the Chemiluminescent Detection of DNA and Proteins. Small, 2: 1037–1041. doi: 10.1002/smll.200600133

Author Information

  1. Institute of Chemistry, The Farkas Center of Light-Induced Processes, The Hebrew University of Jerusalem, Jerusalem 91904, Israel, Fax: (+972) 2-652-7715

  1. †

    This project was supported by the Israel Ministry of Science as an Infrastructure Project.

Publication History

  1. Issue published online: 28 JUL 2006
  2. Article first published online: 13 JUL 2006
  3. Manuscript Received: 15 MAR 2006

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Keywords:

  • biosensors;
  • catalysis;
  • DNA;
  • luminescence;
  • nanoparticles

Graphical Abstract

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Look at the label: Nucleic acid functionalized Pt nanoparticles act as catalysts for the generation of chemiluminescence in the presence of H2O2 and luminol. The functionalized Pt nanoparticles can then be utilized as catalytic labels to detect either DNA or the aptamer–thrombin complex. The efficacy of these labels is favorable when compared with other similar systems.

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