Immunoisolating Pancreatic Islets by Encapsulation with Selective Withdrawal

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Errata

This article is corrected by:

  1. Errata: Retraction: Immunoisolating Pancreatic Islets by Encapsulation with Selective Withdrawal Volume 6, Issue 24, 2780, Article first published online: 14 December 2010

Abstract

This manuscript reports the application of the selective-withdrawal coating technique to the microencapsulation of insulin-producing pancreatic islets within thin poly(ethylene glycol) coatings. These polymer coatings permit the islets to respond to changes in glucose concentration by producing insulin with a dose-response profile that is substantially similar to that of unencapsulated islets. Furthermore, the hydrogel capsules exclude the large molecules of the immune system. These results suggest that the microencapsulation technique—which combines droplet formation from a flow of two immiscible fluids with polymerization chemistries—has the characteristics required for the transplantation of islets for the treatment of Type I diabetes.

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