We acknowledge the financial support of the Danish Ministry for Science, Technology, and Innovation through the iNANO Center. We would like to thank Erik Mortensen for help with the preparation of Figure 1.
Nanocarrier Stimuli-Activated Gene Delivery†
Article first published online: 9 NOV 2006
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 3, Issue 1, pages 54–57, January 2, 2007
How to Cite
Howard, Kenneth A., Dong, M., Oupicky, D., Bisht, Harender S., Buss, C., Besenbacher, F. and Kjems, J. (2007), Nanocarrier Stimuli-Activated Gene Delivery. Small, 3: 54–57. doi: 10.1002/smll.200600328
- Issue published online: 19 DEC 2006
- Article first published online: 9 NOV 2006
- Manuscript Received: 6 JUL 2006
- atomic force microscopy;
- gene delivery;
Gene genie: Stimuli-activated changes in gene-delivery systems are investigated using AFM. Thermoresponsive nanocarriers (see image) show size increases over a scale range that can be exploited for site-specific deposition. Redox-responsive nanocarriers in intracellular environment conditions disassemble into the component parts. These findings highlight the importance of research at the pharmaceutical–nanotechnology interface in the development of next-generation drug-delivery systems.