Communication

Nanocarrier Stimuli-Activated Gene Delivery†

  1. Kenneth A. Howard Dr.1,
  2. Mingdong Dong2,
  3. David Oupicky Dr.3,
  4. Harender S. Bisht Dr.3,
  5. Claus Buss1,
  6. Flemming Besenbacher Prof.2,
  7. Jørgen Kjems Prof.1

Article first published online: 9 NOV 2006

DOI: 10.1002/smll.200600328

Issue

Small

Small

Volume 3, Issue 1, pages 54–57, January 2, 2007

Additional Information

How to Cite

Howard, Kenneth A., Dong, M., Oupicky, D., Bisht, Harender S., Buss, C., Besenbacher, F. and Kjems, J. (2007), Nanocarrier Stimuli-Activated Gene Delivery. Small, 3: 54–57. doi: 10.1002/smll.200600328

Author Information

  1. 1

    Interdisciplinary Nanoscience Center and Department of Molecular Biology, University of Aarhus, 8000 Aarhus C, Denmark, Fax: (+45) 894-236-90

  2. 2

    Interdisciplinary Nanoscience Center and Department of Physics and Astronomy, University of Aarhus, 8000 Aarhus C, Denmark, Fax: (+45) 8942-3690

  3. 3

    Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI 48201, USA

  1. †

    We acknowledge the financial support of the Danish Ministry for Science, Technology, and Innovation through the iNANO Center. We would like to thank Erik Mortensen for help with the preparation of Figure 1.‡

Publication History

  1. Issue published online: 19 DEC 2006
  2. Article first published online: 9 NOV 2006
  3. Manuscript Received: 6 JUL 2006

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Keywords:

  • atomic force microscopy;
  • DNA;
  • gene delivery;
  • nanocarriers;
  • polymers
Thumbnail image of graphical abstract

Gene genie: Stimuli-activated changes in gene-delivery systems are investigated using AFM. Thermoresponsive nanocarriers (see image) show size increases over a scale range that can be exploited for site-specific deposition. Redox-responsive nanocarriers in intracellular environment conditions disassemble into the component parts. These findings highlight the importance of research at the pharmaceutical–nanotechnology interface in the development of next-generation drug-delivery systems.

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