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Keywords:

  • atomic force microscopy;
  • DNA;
  • gene delivery;
  • nanocarriers;
  • polymers
Thumbnail image of graphical abstract

Gene genie: Stimuli-activated changes in gene-delivery systems are investigated using AFM. Thermoresponsive nanocarriers (see image) show size increases over a scale range that can be exploited for site-specific deposition. Redox-responsive nanocarriers in intracellular environment conditions disassemble into the component parts. These findings highlight the importance of research at the pharmaceutical–nanotechnology interface in the development of next-generation drug-delivery systems.