J.L. and M.L. contributed equally to this work. We thank Thoi D. Nguyen for helpful experiments and discussions. This work is supported by the US National Institutes of Health (grant no. CA32737), the National Science Foundation (grant no. DMR 0346601), and the University of California (UC) Lead Campus for Nanotoxicology Training and Research, funded by the UC TSR&TP.
Mesoporous Silica Nanoparticles as a Delivery System for Hydrophobic Anticancer Drugs†
Article first published online: 13 JUN 2007
Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 3, Issue 8, pages 1341–1346, August 3, 2007
How to Cite
Lu, J., Liong, M., Zink, Jeffrey I. and Tamanoi, F. (2007), Mesoporous Silica Nanoparticles as a Delivery System for Hydrophobic Anticancer Drugs. Small, 3: 1341–1346. doi: 10.1002/smll.200700005
- Issue published online: 26 JUL 2007
- Article first published online: 13 JUN 2007
- Manuscript Revised: 13 APR 2007
- Manuscript Received: 6 JAN 2007
- anticancer agents;
- drug delivery;
Special delivery: The hydrophobic anticancer drug camptothecin was incorporated into fluorescent mesoporous silica nanoparticles (see image) and delivered to various cancer cells to induce cell death. These results suggest a method to overcome the insolubility problem of many anticancer drugs, which is considered to be one of the major challenges in cancer therapy.