The work was performed at Pacific Northwest National Laboratory (PNNL) and supported partially by grant number NS058161-01 from the National Institutes of Health CounterACT Program through the National Institute of Neurological Disorders and Stroke, and partially by grant number U54 ES16015 from the National Institute of Environmental Health Sciences (NIEHS) NIH. The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. The work was performed at the Environmental Molecular Sciences Laboratory, a national scientific user facility sponsored by the U.S. Department of Energy (DOE) and located at PNNL. PNNL is operated by Battelle for DOE under Contract DE-AC05-76RL01830.
Quantum-Dot-Based Electrochemical Immunoassay for High-Throughput Screening of the Prostate-Specific Antigen†
Article first published online: 14 DEC 2007
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 4, Issue 1, pages 82–86, January 18, 2008
How to Cite
Wang, J., Liu, G., Wu, H. and Lin, Y. (2008), Quantum-Dot-Based Electrochemical Immunoassay for High-Throughput Screening of the Prostate-Specific Antigen. Small, 4: 82–86. doi: 10.1002/smll.200700459
- Issue published online: 11 JAN 2008
- Article first published online: 14 DEC 2007
- Manuscript Revised: 30 OCT 2007
- Manuscript Received: 29 JUN 2007
- electrochemical methods;
- high-throughput screening;
- quantum dots
Biosensing platform for immunoreactions: An electrochemical high-throughput sensing platform for simple, sensitive detection of prostate-specific serum antigen (PSA) based on quantum dot (QD) labels is demonstrated (see figure). The high sensitivity stems from the dual signal amplification via QD labels and preconcentration, allowing for detection of extremely low concentrations while using small sample volumes.