Design of an Amphiphilic Polymer for Nanoparticle Coating and Functionalization

Authors

  • Cheng-An J. Lin,

    1. Center for NanoScience, Ludwig-Maximilians-Universität München, Munich, Germany
    2. Department of Biomedical Engineering, Chung Yuan Christian University, Taiwan, ROC
    3. R&D Center for Membrane Technology, Center for Nano Bioengineering, Chung Yuan Christian University, Taiwan, ROC
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    • These authors contributed equally to this work.

  • Ralph A. Sperling,

    1. Fachbereich Physik, Philipps Universität Marburg, Renthof 7, 35037 Marburg, Germany
    2. Center for NanoScience, Ludwig-Maximilians-Universität München, Munich, Germany
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    • These authors contributed equally to this work.

  • Jimmy K. Li,

    1. R&D Center for Membrane Technology, Center for Nano Bioengineering, Chung Yuan Christian University, Taiwan, ROC
    2. Present address: Institute of Biotechnology, National Cheng Kung University, Taiwan, ROC
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  • Ting-Ya Yang,

    1. Department of Biomedical Engineering, Chung Yuan Christian University, Taiwan, ROC
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  • Pei-Yun Li,

    1. Center for NanoScience, Ludwig-Maximilians-Universität München, Munich, Germany
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  • Marco Zanella,

    1. Fachbereich Physik, Philipps Universität Marburg, Renthof 7, 35037 Marburg, Germany
    2. Center for NanoScience, Ludwig-Maximilians-Universität München, Munich, Germany
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  • Walter H. Chang,

    1. Department of Biomedical Engineering, Chung Yuan Christian University, Taiwan, ROC
    2. R&D Center for Membrane Technology, Center for Nano Bioengineering, Chung Yuan Christian University, Taiwan, ROC
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  • Wolfgang J. Parak Prof.

    1. Fachbereich Physik, Philipps Universität Marburg, Renthof 7, 35037 Marburg, Germany
    2. Center for NanoScience, Ludwig-Maximilians-Universität München, Munich, Germany
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  • The authors are grateful to the DAAD-NSC sandwich program for facilitating this project. The German and Taiwanese partners were funded by the German research foundation (DFG Emmy Noether fellowship) and the European Union (SA-Nano grant), and by the National Nanotechnology Program (NSC) and the Center of Excellence (MOE) of Taiwan, respectively. Marco Zanella acknowledges a fellowship from the ITKD graduate school at the Center for Nanoscience in Munich. We are very grateful to Prof. Dr. Warren Chan for many important ideas and valuable technical discussions. We are also grateful to Maria Teresa Fernandez and to Dr. Feng Zhang for experimental support and technical discussions at different stages of the project and to Dr. Maria Casula for help in the synthesis of iron oxide nanoparticles.

Abstract

original image

Amphiphilic polymer-coating for nanoparticles: The facile one-pot synthesis of a comblike polymer can be tailored in order to vary its hydrophobic side-chains or to directly incorporate functional molecules without the need for crosslinkers. This leads to a general and robust method of phase-transfer of hydrophobic nanoparticles to aqueous solution, as well as to their modification with functional molecules.

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