This work has been financially supported by the Korea Science and Engineering Foundation through the National Core Research Center for Nanomedical Technology (Grant No. R15-20040924-00000-0).
Multifunctional Nanoparticles for Photothermally Controlled Drug Delivery and Magnetic Resonance Imaging Enhancement†
Article first published online: 18 JAN 2008
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 4, Issue 2, pages 192–196, February 1, 2008
How to Cite
Park, H., Yang, J., Seo, S., Kim, K., Suh, J., Kim, D., Haam, S. and Yoo, K.-H. (2008), Multifunctional Nanoparticles for Photothermally Controlled Drug Delivery and Magnetic Resonance Imaging Enhancement. Small, 4: 192–196. doi: 10.1002/smll.200700807
- Issue published online: 4 FEB 2008
- Article first published online: 18 JAN 2008
- Manuscript Revised: 12 DEC 2007
- Manuscript Received: 5 SEP 2007
- contrast enhancement;
- core/shell materials;
- magnetic resonance imaging
Core–multishell nanoparticles: Near-IR-resonant rhodamine-encapsulated poly(lactic-co-glycolic acid) (PLGA)–Mn/Au half-shell nanoparticles (NPs; see figure) are developed by depositing metal multilayers on PLGA NPs. These NPs can be used for photothermally controlled drug delivery and magnetic resonance imaging. Upon NIR irradiation, the release rate of rhodamine from the PLGA NPs is about twice as great as that without NIR irradiation, indicating photothermally controlled drug delivery possibilities.