Communication

Multifunctional Nanoparticles for Photothermally Controlled Drug Delivery and Magnetic Resonance Imaging Enhancement†

  1. Huiyul Park1,
  2. Jaemoon Yang2,
  3. Sungbaek Seo2,
  4. Kyujung Kim3,
  5. Jinsuk Suh Prof.4,
  6. Donghyun Kim Prof.3,
  7. Seungjoo Haam2,
  8. Kyung-Hwa Yoo Prof.1

Article first published online: 18 JAN 2008

DOI: 10.1002/smll.200700807

Issue

Small

Small

Volume 4, Issue 2, pages 192–196, February 1, 2008

Additional Information

How to Cite

Park, H., Yang, J., Seo, S., Kim, K., Suh, J., Kim, D., Haam, S. and Yoo, K.-H. (2008), Multifunctional Nanoparticles for Photothermally Controlled Drug Delivery and Magnetic Resonance Imaging Enhancement. Small, 4: 192–196. doi: 10.1002/smll.200700807

Author Information

  1. 1

    Department of Physics, Yonsei University, Seoul 120-742, Korea, Fax: (+82) 231-270-90

  2. 2

    Department of Chemical Engineering, Yonsei University, Seoul 120-742, Korea

  3. 3

    Department of Electrical and Electronic Engineering, Yonsei University, Seoul 120-742, Korea

  4. 4

    Department of Radiology, College of Medicine, Yonsei University, Seoul 120-752, Korea

  1. †

    This work has been financially supported by the Korea Science and Engineering Foundation through the National Core Research Center for Nanomedical Technology (Grant No. R15-20040924-00000-0).

Publication History

  1. Issue published online: 4 FEB 2008
  2. Article first published online: 18 JAN 2008
  3. Manuscript Revised: 12 DEC 2007
  4. Manuscript Received: 5 SEP 2007

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Keywords:

  • contrast enhancement;
  • core/shell materials;
  • encapsulation;
  • gold;
  • magnetic resonance imaging
Thumbnail image of graphical abstract

Core–multishell nanoparticles: Near-IR-resonant rhodamine-encapsulated poly(lactic-co-glycolic acid) (PLGA)–Mn/Au half-shell nanoparticles (NPs; see figure) are developed by depositing metal multilayers on PLGA NPs. These NPs can be used for photothermally controlled drug delivery and magnetic resonance imaging. Upon NIR irradiation, the release rate of rhodamine from the PLGA NPs is about twice as great as that without NIR irradiation, indicating photothermally controlled drug delivery possibilities.

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