Multifunctional Nanoparticles for Photothermally Controlled Drug Delivery and Magnetic Resonance Imaging Enhancement


  • This work has been financially supported by the Korea Science and Engineering Foundation through the National Core Research Center for Nanomedical Technology (Grant No. R15-20040924-00000-0).


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Core–multishell nanoparticles: Near-IR-resonant rhodamine-encapsulated poly(lactic-co-glycolic acid) (PLGA)–Mn/Au half-shell nanoparticles (NPs; see figure) are developed by depositing metal multilayers on PLGA NPs. These NPs can be used for photothermally controlled drug delivery and magnetic resonance imaging. Upon NIR irradiation, the release rate of rhodamine from the PLGA NPs is about twice as great as that without NIR irradiation, indicating photothermally controlled drug delivery possibilities.