A. A. and S. N. contributed equally to this work. This work was supported in part by NCI grant CA101781 and by a UCF-NSTC Start-Up Fund, all to J. M. P. The authors acknowledge the help of Zia Ur Rahman and Kirk Scammon from the Advanced Material Processing and Analysis Center (AMPAC) at UCF for technical assistance.
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Communication
Synthesis of Biocompatible Dextran-Coated Nanoceria with pH-Dependent Antioxidant Properties†
Article first published online: 24 APR 2008
DOI: 10.1002/smll.200700824
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Perez, J. M., Asati, A., Nath, S. and Kaittanis, C. (2008), Synthesis of Biocompatible Dextran-Coated Nanoceria with pH-Dependent Antioxidant Properties. Small, 4: 552–556. doi: 10.1002/smll.200700824
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Publication History
- Issue published online: 19 MAY 2008
- Article first published online: 24 APR 2008
- Manuscript Revised: 16 JAN 2008
- Manuscript Received: 10 SEP 2007
Funded by
- NCI. Grant Number: CA101781
- UCF-NSTC Start-Up Fund
Keywords:
- antioxidants;
- cerium oxide;
- dextran;
- nanoceria;
- pH dependence
Biocompatible dextran-coated nanoceria (cerium oxide nanoparticles) are found to exhibit excellent, pH-dependent antioxidant properties (see image). They provide cytoprotection from free radicals to normal cells but not to cancer cells, and thus have potential applications in antioxidant and anti-inflammatory coatings for prosthetic devices and tissue engineering and in improved cancer therapeutics.