Synthesis of Biocompatible Dextran-Coated Nanoceria with pH-Dependent Antioxidant Properties

Authors

  • J. Manuel Perez,

    Corresponding author
    1. Nanoscience Technology Center, Department of Chemistry, and Burnett School of Biomedical Sciences University of Central Florida 12424 Research Parkway, Suite 400 Orlando, FL 32826 (USA)
    • Nanoscience Technology Center, Department of Chemistry, and Burnett School of Biomedical Sciences University of Central Florida 12424 Research Parkway, Suite 400 Orlando, FL 32826 (USA) Fax: (+1) 467-882-2843
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  • Atul Asati,

    1. Nanoscience Technology Center, Department of Chemistry, and Burnett School of Biomedical Sciences University of Central Florida 12424 Research Parkway, Suite 400 Orlando, FL 32826 (USA)
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  • Sudip Nath,

    1. Nanoscience Technology Center, Department of Chemistry, and Burnett School of Biomedical Sciences University of Central Florida 12424 Research Parkway, Suite 400 Orlando, FL 32826 (USA)
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  • Charalambos Kaittanis

    1. Nanoscience Technology Center, Department of Chemistry, and Burnett School of Biomedical Sciences University of Central Florida 12424 Research Parkway, Suite 400 Orlando, FL 32826 (USA)
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  • A. A. and S. N. contributed equally to this work. This work was supported in part by NCI grant CA101781 and by a UCF-NSTC Start-Up Fund, all to J. M. P. The authors acknowledge the help of Zia Ur Rahman and Kirk Scammon from the Advanced Material Processing and Analysis Center (AMPAC) at UCF for technical assistance.

Abstract

original image

Biocompatible dextran-coated nanoceria (cerium oxide nanoparticles) are found to exhibit excellent, pH-dependent antioxidant properties (see image). They provide cytoprotection from free radicals to normal cells but not to cancer cells, and thus have potential applications in antioxidant and anti-inflammatory coatings for prosthetic devices and tissue engineering and in improved cancer therapeutics.

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