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Chemoselective Nanowire Fuses: Chemically Induced Cleavage and Electrical Detection of Carbon Nanofiber Bridges
Article first published online: 5 JUN 2008
DOI: 10.1002/smll.200700944
Copyright © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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Additional Information
How to Cite
Li, B., Shang, L., Marcus, M. S., Clare, T. L., Perkins, E. and Hamers, R. J. (2008), Chemoselective Nanowire Fuses: Chemically Induced Cleavage and Electrical Detection of Carbon Nanofiber Bridges. Small, 4: 795–801. doi: 10.1002/smll.200700944
Publication History
- Issue published online: 16 JUN 2008
- Article first published online: 5 JUN 2008
- Manuscript Revised: 25 JAN 2008
- Manuscript Received: 8 OCT 2007
Funded by
- National Science Foundation. Grant Numbers: DMR-0425880, DMR-0210806
- Abstract
- Article
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Keywords:
- biosensors;
- disulfides;
- molecular recognition;
- nanoelectronics;
- switches
Abstract
A new type of nanoscale bioswitch based on the electrical detection of chemically induced cleavage of chemical bonds, which bind individual nanowires across a pair of electrodes is demonstrated. Carbon nanofibers are manipulated using dielectrophoresis to form single-nanowire bridges across microelectrode junctions, and are anchored through a biomolecular interaction. Once in place, chemically induced cleavage of a recognition site along the bonds linking the nanowire to the electrodes allows the nanowire to be easily removed by a flow of fluid; this removal can be detected in real time via changes in the AC electrical response. This form of sensing is inherently digital in nature as the removal of a single nanowire produces a sudden decrease in the current between electrodes and is essentially a chemoselective fuse. These results suggest that this sensing principle could be a general method for digital chemical and/or biological sensing using individual nanowires.