These authors contributed equally to this work.
Analysis of the Toxic Mode of Action of Silver Nanoparticles Using Stress-Specific Bioluminescent Bacteria†
Article first published online: 4 JUN 2008
Copyright © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 4, Issue 6, pages 746–750, June 2008
How to Cite
Hwang, E. T., Lee, J. H., Chae, Y. J., Kim, Y. S., Kim, B. C., Sang, B.-I. and Gu, M. B. (2008), Analysis of the Toxic Mode of Action of Silver Nanoparticles Using Stress-Specific Bioluminescent Bacteria. Small, 4: 746–750. doi: 10.1002/smll.200700954
This research was supported by the Ministry of Environment as “The Eco-technopia 21 project”. The authors are grateful for this support.
- Issue published online: 16 JUN 2008
- Article first published online: 4 JUN 2008
- Manuscript Revised: 7 JAN 2008
- Manuscript Received: 9 OCT 2007
- cell damage;
- reactive oxygen species;
- silver nanoparticles;
Every cell has a silver lining! The toxicity of Ag nanoparticles is investigated using a panel of recombinant bioluminescent bacteria. The presence of the nanoparticles leads to the production of a superoxide radical (see figure). Furthermore, the Ag nanoparticles damage the cellular membranes, causing a disruption in the ion efflux system. Thus, the cells cannot effectively extrude the Ag ions and, hence, Ag nanoparticles cause more damage than do Ag ions.