Communication

Fluorescent Core/Shell Nanoparticles for Specific Cell-Nucleus Staining†

  1. Meizhen Yin1,
  2. Jie Shen2,*,
  3. Radu Gropeanu1,
  4. Gert O. Pflugfelder2,
  5. Tanja Weil1,*,
  6. Klaus Müllen1,*

Article first published online: 17 JUN 2008

DOI: 10.1002/smll.200701107

Issue

Small

Small

Volume 4, Issue 7, pages 894–898, July 2008

Additional Information

How to Cite

Yin, M., Shen, J., Gropeanu, R., Pflugfelder, G. O., Weil, T. and Müllen, K. (2008), Fluorescent Core/Shell Nanoparticles for Specific Cell-Nucleus Staining. Small, 4: 894–898. doi: 10.1002/smll.200701107

Author Information

  1. 1

    Max Planck Institute for Polymer Research Ackermannweg 10 55128 Mainz (Germany)

  2. 2

    Institute of Genetics, Johannes Gutenberg University Becherweg 32 55128 Mainz (Germany)

*Institute of Genetics, Johannes Gutenberg University Becherweg 32 55128 Mainz (Germany).

  1. †

    This work was financially supported by the Deutsche Forschungsgemeinschaft (SFB 625). We thank Prof. Dr. G. Bodwell for comments on the manuscript.

Publication History

  1. Issue published online: 11 JUL 2008
  2. Article first published online: 17 JUN 2008
  3. Manuscript Revised: 18 JAN 2008
  4. Manuscript Received: 12 NOV 2007

Funded by

  • Deutsche Forschungsgemeinschaft. Grant Number: SFB 625

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Keywords:

  • carboxylic acid;
  • cell nucleus;
  • core/shell nanoparticles;
  • histochemistry;
  • histones
Thumbnail image of graphical abstract

Water-soluble fluorescent core/shell nanoparticles containing multiple -COOH groups are synthesized via atom-transfer radical polymerization by applying perylenediimide derivatives as the template. This novel dye combines good water-solubility and attractive optical properties. It specifically stains the cell nucleus by binding to positively charged nuclear proteins (see image).

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