Controlled Growth of Peptide Nanoarrays on Si/SiOx Substrates

Authors

  • Xiaozhu Zhou,

    1. School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore 639798 (Singapore)!
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    • These authors contribute equally to this work.

  • Yanhong Chen,

    1. School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore 639798 (Singapore)!
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    • These authors contribute equally to this work.

  • Bing Li,

    1. School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore 639798 (Singapore)!
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    • These authors contribute equally to this work.

  • Gang Lu,

    1. School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore 639798 (Singapore)!
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  • Freddy Y. C. Boey,

    1. School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore 639798 (Singapore)!
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  • Jan Ma,

    1. School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore 639798 (Singapore)!
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  • Hua Zhang

    Corresponding author
    1. School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore 639798 (Singapore)!
    • School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore 639798 (Singapore). Fax: (+65) 6790-9081
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  • This work was supported by the Start-Up Grant from NTU and AcRF Tier 1 from MOE in Singapore. The authors acknowledge Professor Rongchao Jin at Carnegie Mellon University for editing the manuscript.

Abstract

original image

PAMAM dendrimer nanopatterns on Si/ SiOx substrates generated by dip-pen nanolithography are used as anchoring scaffolds for the growth of peptides in situ by ring-opening polymerization of tryptophan-N-carboxyanhydrides. This new method for the fabrication of peptide nanoarrays (see image) on a solid substrate is unique in that the growth of peptide nanostructures is controlled by the reaction time and the concentration of the tryptophan species.

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