Metallic Iron Nanoparticles for MRI Contrast Enhancement and Local Hyperthermia


  • This work was supported in part by grants from the Georgia Cancer Coalition, Distinguished Cancer Clinicians and Scientists Program (C. G. H.), NIH Center for Cancer Nanotechnology in Excellence Program (H. M.), EmTech Bio, Inc (H. M.), and NSF DMR 0302544 (G. C. H.).


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New metallic magnetic nanoparticles with greater magnetic properties than current iron oxide nanoparticles (IONPs) of comparable size (10 nm) are described. The multifunctional iron-based NPs coated with biocompatible carboxyl-terminated polyethylene glycol (see image) generate more effective local hyperthermia when subjected to an oscillating magnetic field and have a stronger MRI T2 shortening effect than IONPs.